The at the Ï㽶ÊÓƵ of Utah has awarded seed grants to eight projects that support the initiative's aim of exploring the fundamental function of the immune system as it relates to infectious and autoimmune diseases, like diabetes and heart disease.
"The immune system is involved in just about every human disease," says Ryan O'Connell, director of the III initiative and an associate professor in pathology at U of U Health. "We believe that these seed grants will provide the initial support needed for our research teams to compete successfully for future funding. Ultimately, this work will improve our understanding of how the immune system impacts a number of devastating human disorders, and should be the foundation for developing novel therapies to be used in the clinic."
The projects span an array of topics, from obesity-related inflammation and insulin resistance to the association between colorectal cancer and the gut microbiome. Each grant was awarded $50,000 for one year. The 2018 awardees are:
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The Role of Stra6L In Obesity Related Inflammation and Insulin Resistance*
., Department of Nutrition and Integrative Physiology
., Department of Pathology
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The Identification of Biomarkers for Psoriatic Arthritis Early Diagnosis*
., Department of Dermatology
Jessica Walsh, MD., Department of Internal Medicine
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Epigenetic Regulation of Innate Lymphocyte Suppression in Human and Experimental Sepsis*
Daniel Leung, MD, MSC, Department of Internal Medicine
., Department of Pathology
Matt Rondina, MD, MS, Department of Internal Medicine
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Molecular and Functional Role of Neutrophils in Squamous Cell Lung Cancer*
., Department of Oncological Sciences
., Department of Pathology
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The Immunometagenomic Landscape of Colorectal Cancer: Associations Between Immune-Cell Infiltrate in Colorectal Carcinoma and The Gut Microbiome*
., Department of Population Health Sciences
Eric Swanson, MD, Department of Pathology
., Department of Pathology
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Image-Guided Delivery of T Cell Receptor (TCR)-Transgenic T Cells Targeting Hepatocellular Carcinoma*
Gabriel Fine, MD, Department of Radiology
Djordje Atanackovic, MD, Department of Internal Medicine
, Department of Pathology
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Role of Ceramide Accumulation in Effector T and Treg Cells in Development of Insulin Resistance**
Bhagirath Chaurasia, PhD, Department of Nutrition and Integrative Physiology
, Department of Pathology
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Turning T Follicular Helper Cells "On" to Enhance Anti-Malarial Humoral Immunity***
, Department of Pathology
, Department of Pathology
*Funded by the Senior Vice President for Health Sciences and the Vice President for Research
**Funded by the Diabetes and Metabolism Research Center
***Funded by the Department of Pathology
The III seed grants fund pilot projects that promote collaborations among at least two independent investigators or research groups at U of U Health. Seed grants provide initial support to develop preliminary data that will allow competitive applications for funding by the NIH or other agencies and foundations.
III was created to improve diagnosis and treatment for this diverse array of disorders. It is built on a strong foundation of more than 100 faculty who conduct research in related fields at 4 colleges or schools and 20 departments across campus. A major goal of this initiative is to integrate basic, translational and clinical research in these areas by strengthening the III community and fostering collaborations.